Detalhe da pesquisa
1.
Ziritaxestat, a Novel Autotaxin Inhibitor, and Lung Function in Idiopathic Pulmonary Fibrosis: The ISABELA 1 and 2 Randomized Clinical Trials.
JAMA
; 329(18): 1567-1578, 2023 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37159034
2.
Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A.
J Immunol
; 201(8): 2377-2384, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30158125
3.
IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease.
J Allergy Clin Immunol
; 142(2): 435-450.e10, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29108965
4.
Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation.
J Immunol
; 197(4): 1322-34, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27421477
5.
Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism.
J Immunol
; 197(5): 1720-32, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27465529
6.
Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma.
Am J Respir Cell Mol Biol
; 55(2): 176-87, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27064658
7.
Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice.
Am J Respir Cell Mol Biol
; 55(3): 377-86, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27035878
8.
Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: the materialization of the hormesis concept.
Biochem Biophys Res Commun
; 446(4): 1029-34, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24667599
9.
ISABELA Studies: Plasma Exposure and Target Engagement Do Not Explain the Lack of Efficacy of Ziritaxestat in Patients with Idiopathic Pulmonary Fibrosis.
Clin Pharmacol Ther
; 115(3): 606-615, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38071462
10.
Acrolein exposure suppresses antigen-induced pulmonary inflammation.
Respir Res
; 14: 107, 2013 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24131734
11.
A 24-Week, Phase IIa, Randomized, Double-Blind, Placebo-Controlled Study of Ziritaxestat in Early Diffuse Cutaneous Systemic Sclerosis.
Arthritis Rheumatol
; 75(8): 1434-1444, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36787101
12.
The tobacco smoke component, acrolein, suppresses innate macrophage responses by direct alkylation of c-Jun N-terminal kinase.
Am J Respir Cell Mol Biol
; 46(1): 23-33, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21778411
13.
Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models.
Front Bioeng Biotechnol
; 6: 154, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30430109
14.
Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome.
Redox Biol
; 12: 883-896, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28463821
15.
The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase.
Toxicol Lett
; 240(1): 43-9, 2016 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26481333
16.
Inhalation of the reactive aldehyde acrolein promotes antigen sensitization to ovalbumin and enhances neutrophilic inflammation.
J Immunotoxicol
; 13(2): 191-7, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-25875327
17.
Anti-inflammatory effects of levalbuterol-induced 11ß-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells.
Front Endocrinol (Lausanne)
; 5: 236, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25628603
18.
Protein alkylation by the α,ß-unsaturated aldehyde acrolein. A reversible mechanism of electrophile signaling?
FEBS Lett
; 587(23): 3808-14, 2013 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24157358
19.
Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1.
Redox Biol
; 1: 265-75, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24024160